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Figure 2 | Molecular Brain

Figure 2

From: A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-α

Figure 2

Signalling mechanisms involved in mAChR-LTD. (A) Cyclopiazonic acid (2 μM) has no effect on mAChR-LTD (n = 6). (B) Ro 32-0432 (10 μM) has no effect on mAChR-LTD (n = 6). (C) Okadaic acid (100 nM) has no effect on mAChR-LTD (n = 5). (D) Anisomycin (20 μM) has no effect on mAChR-LTD (n = 7). (E) Orthovanadate (100 μM) prevents the induction of mAChR-LTD (n = 5). (F) GDPβS (1 mM) blocks the induction of mAChR-LTD (n = 6). (G) A summary of results from control (n = 8), BAPTA (n = 9), cyclopiazonic acid (n = 6), PKC19–31 (n = 9), Ro 32-0432 (n = 6), okadaic acid (n = 5), cyclosporin A (n = 7), anisomycin (n = 7), cycloheximide (n = 7), orthovanadate (n = 5), phenylarsine oxide (n = 7) and GDPβS (n = 6), experiments. * P < 0.05 vs control ** P < 0.01 vs control.

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