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Figure 6 | Molecular Brain

Figure 6

From: Maternal epileptic seizure induced by Pentylenetetrazol: Apoptotic neurodegeneration and decreased GABAB1 receptor expression in prenatal rat brain

Figure 6

(a, b) PTZ-induced seizure during pregnancy decreases the mRNA level of PKA-α in prenatal rat hippocampal neurons. A: RT-PCR analyses change in mRNA (6a) and protein level (6b) of the PKA-α in the primary cultured hippocampal neuronal cells at GD 17.5 from PTZ-induced seizure model during pregnancy. Cells are exposed to different drugs for 20 min as previously explained. Detail procedures are mentioned in material and method section. GAPDH and β-actin is taken as control. In case of Western blot analysis immunoblots were labeled with an anti PKA antibody. B: Density values were expressed as mean ± SEM (n = 4, mean four rat per group) of the corresponding mRNA of GABAB1R and PKA are presented. The density values on (Y-axis) are expressed as arbitrary units (AU). *P < 0.05 and **P < 0.01 versus control group.

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