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Figure 1 | Molecular Brain

Figure 1

From: A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases

Figure 1

GSK-3 inhibitors block the induction of LTD. A, A single experiment (upper) and pooled data from 28 experiments (lower) illustrating LTD under control conditions. B, A single experiment (upper) and pooled data from 6 experiments (lower) illustrating the block of LTD by CT99021 (1 μM). C, A single experiment (upper) and pooled data from 5 experiments (lower) illustrating the block of LTD by AR-164 (1 μM). D, Pooled data from 3 experiments illustrating the effect of PenCTRL (20 μM) on LTD. E, Pooled data from 3 experiments illustrating blockade of LTD by penGSKi (20 μM). In each panel, the points are the average amplitude of 6 successive EPSCs normalised with respect to the baseline. At t = 0, the neuron was depolarised to -40 mV and stimuli delivered at 0.66 Hz to the test input for the duration indicated by the bar. EPSCs (average of 6 consecutive records) obtained before and following the induction of LTD are illustrated at the times indicated (1, 2). The calibration bars for the traces depict 50 pA and 50 ms.

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Molecular Brain

ISSN: 1756-6606