Figure 2
From: Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin
The Enlargement of Rab5-positive endosomes in ALS2-/- neurons may correlate with increased Rab5 activities. Representative images of wild-type (WT) and ALS2-/- (KO) hippocampal neurons transfected with GFP-Rab5S (A and B) or GFP-Rab5Q (C and D). Fragments of soma (inset) were enlarged to reveal the distribution and morphology of Rab5-positive vesicles. Scale bar: 20 μm (main) and 5 μm (inset).