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Figure 7 | Molecular Brain

Figure 7

From: Cocaine induces cell death and activates the transcription nuclear factor kappa-b in pc12 cells

Figure 7

Schematic representation of neurotoxic action of cocaine in PC12 cells. The treatment of PC 12 cells with cocaine can alter the Bax/Bcl-2 ratio, reducing the Bcl2 levels, which could lead to activation of caspase 3 and the trigger of cell death process, seen after 24 hours of treatment. On the other hand, to protect the cell from cocaine-toxic effects activation of NF-κB occurs through D1 receptors. The activation of this transcription factor could lead to transcription of anti-apoptotic genes, such as BDNF that tries to mimitaze the process of cell death.

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