Figure 3

Loss of dTDP-43 activity led to decreased dendritic branching. (A) Dendritic branching pattern of ddaE and ddaF neurons in a wildtype larva. (B) ddaE and daF neurons in a dTDP-43^{Q 367X}homozygous mutant third instar larva. The neurons in A and B were labeled with mCD8-GFP under the control of Gal4²²¹. (C) Quantification of dendritic ends of ddaE neurons. (D) Quantification of dendritic ends of ddaF neurons. The number of neurons examined is indicated in each column. Values are mean ± SEM ***P < 0.001. The effect of loss of dTDP-43 function on dendritic formation was confirmed by expressing two independent UAS-dTDP-43 RNAi constructs, 38377 and 38379, in ddaE and ddaF neurons in the dTDP-43^{Q 367X}/+ background.