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Figure 2 | Molecular Brain

Figure 2

From: Characterization of intracortical synaptic connections in the mouse anterior cingulate cortex using dual patch clamp recording

Figure 2

Excitatory synaptic transmission in the ACC. ( A ) Diagram and sample traces of synaptic connections from pyramidal neurons to pyramidal neurons. Pre, action potential is induced in the presynaptic pyramidal neuron under current clamp. Post, inward uEPSCs with failure are recorded in the postsynaptic neuron under voltage clamp holding at --70 mV. Average, the trace of the average of 10 original traces. ( B ) Diagram and sample traces of synaptic connections from pyramidal neurons to interneurons. ( C ) Pooled data (open circle and triangle) and summarized results (bar graph) showing the amplitude of uEPSCs for Py-Py and Py-In. n.s., no significance. ( D-G ) Pooled data (open circle and triangle) and summarized results (bar graph) indicate the latency (D), rise time (E), decay time (F) and half-width (G) of uEPSCs for Py-Py and Py-In. Unitary EPSCs from Py-In pairs have faster kinetics than those from Py-Py pairs. * P < 0.05, ** P < 0.01, *** P < 0.001.

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