Calcineurin activity but not protein levels are increased in HdhQ111/Q111 mouse brains. A) Calcineurin levels were analyzed in cortex, striatum and substantia nigra from HdhQ111/Q111 and Hdh+/+ mouse brains. No differences in protein levels were detected between wild type and HD condition. Note that calcineurin levels are lower in substantia nigra compared to cortex and striatum. (B) Calcineurin activity is significantly increased in the cortex of HdhQ111/Q111 and HdhQ111/+ mice compared to Hdh+/+ mice. Data are from 6 mice per condition and were expressed as percentage of calcineurin activity per gram of tissue. (***p < 0.001 for HdhQ111/+ and HdhQ111/Q111). No differences were found between HdhQ111/+ and HdhQ111/Q111 (p = 0.99; NS).