Figure 6

Calcineurin activity but not protein levels are increased in Hdh^Q111/Q111 mouse brains. A) Calcineurin levels were analyzed in cortex, striatum and substantia nigra from Hdh^Q111/Q111 and Hdh^+/+ mouse brains. No differences in protein levels were detected between wild type and HD condition. Note that calcineurin levels are lower in substantia nigra compared to cortex and striatum. (B) Calcineurin activity is significantly increased in the cortex of Hdh^Q111/Q111 and Hdh^Q111/+ mice compared to Hdh^+/+ mice. Data are from 6 mice per condition and were expressed as percentage of calcineurin activity per gram of tissue. (***p < 0.001 for Hdh^Q111/+ and Hdh^Q111/Q111). No differences were found between Hdh^Q111/+ and Hdh^Q111/Q111 (p = 0.99; NS).