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Figure 1 | Molecular Brain

Figure 1

From: Action potential evoked transmitter release in central synapses: insights from the developing calyx of Held

Figure 1

Linearized Buffered Diffusion & Release Site Topography Model. (A) Schematic representation of the single VGCC for which the buffered diffusion model determines [Ca2+] as a function of r. (B) [Ca2+] as a function of r for the various buffer conditions from Fedchyshyn & Wang (2005) in response to the steady-state opening of a single VGCC. (C) [Ca2+]·r as a function of r, or the buffer composition "fingerprint" for the various buffer conditions from Fedchyshyn & Wang (2005) in response to the steady-state opening of a single VGCC. (D) Modeled arrangement of VGCCs in immature (magenta VGCCs) and mature (cyan VGCCs) synapses. ENDO refers to endogenous immobile buffer. Single VGCC flux for all panels F = 6.24 × 105 ions/sec or 0.2pA of constant current. Buffer parameters are as in Naraghi & Neher (1997). Schematics are not drawn to scale.

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Molecular Brain

ISSN: 1756-6606