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Table 1 Parameters for Buffered Ca2+ Diffusion Models

From: Action potential evoked transmitter release in central synapses: insights from the developing calyx of Held

Quantity Immature (P8-12) Mature (P16-18) Reference
ATP Diffusion Constant 220 μm2/s 220 μm2/s 57
Kd (ATP) 2300 μM 2300 μM 57
kon (ATP) 500 μM-1•s-1 500 μM-1•s-1 57
[ATP]pipette 2000 μM 2000 μM 57
EGTA Diffusion Constant 220 μm2/s 220 μm2/s 57
Kd (EGTA) 0.18 μM 0.18 μM 57
kon (EGTA) 2.5 μM-1•s-1 2.5 μM-1•s-1 57
[EGTA]pipette 500/10000 μM 500 μM 36
BAPTA Diffusion Constant 220 μm2/s 220 μm2/s 57
Kd (BAPTA) 0.22 μM 0.22 μM 57
kon (BAPTA) 400 μM-1•s-1 400 μM-1•s-1 57
[BAPTA]pipette 1000 μM 1000 μM 36
ENDO Diffusion Constant 15 μm2/s 15 μm2/s 57
Kd (ENDO) 50 μM 50 μM 57
kon (ENDO) 100 μM-1•s-1 100 μM-1•s-1 57
[ENDO]pipette 500 μM 500 μM 57
Ca2+ Diffusion Constant 220 μm2/s 220 μm2/s 57
Resting [Ca2+]i 50 nM 50 nM 58
Steady-State Single VGCC Flux 6.24 × 105 ions/s 6.24 × 105 ions/s 24