Table 1 Summary of the involvement of NMDA receptor NR2B subunit in synaptic LTP
From: Plasticity of NMDA receptor NR2B subunit in memory and chronic pain
Brain region | Pharmacological inhibitors or genetic manipulation | Induction protocol | Effects on LTP | Reference |
|---|---|---|---|---|
ACC | NR2B antagonist | Pairing protocol | Reduced | Zhao et al., 2005 |
Spike-timing protocol | Blocked | |||
Theta burst stimulation (TBS) | blocked | |||
Perirhinal cortex | NR2B antagonist | High frequency stimulation (HFS) | No effect | Massey et al., 2004 |
Visual cortex | NR2B antagonist | Pairing protocol | blocked | Yoshimura et al., 2003 |
Hippocampal CA1 | NR2B overexpression | HFS or repetitive stimulation | Enhanced | Tang et al., 1999 |
HFS | No effect | Liu et al., 2004 | ||
NR2B antagonist | Pairing protocol | No effect | ||
HFS | Reduced | Berberich et al., 2007 | ||
Pairing protocol | Blocked | |||
HFS | No effect | Zhang et al., 2008 | ||
Pairing protocol | No effect | |||
Spike-timing protocol | blocked | |||
Amygdala | NR2B antagonist | Pairing protocol | Reduced | Miwa et al., 2008 |
Spinal dorsal horn | ND | ND | ND |