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Table 2 Summary of the involvement of NMDA receptor NR2B subunit in behavioral memory and chronic pain

From: Plasticity of NMDA receptor NR2B subunit in memory and chronic pain

Brain function Drug or manipulation Brain regions Effects Reference
Spatial memory (Morris water maze) NR2B overexpression Forebrain Enhanced fear memory Tang et al., 1999
  NR2B antagonist Systemic injection No effect Guscott et al., 2003
Fear memory NR2B overexpression Forebrain Enhanced fear memory Tang et al., 1999
  NR2B antagonist Amygdala Blocked acquisition Rodrigues et al., 2001
    No effect on expression of fear  
  NR2B antagonist Amygdala Inhibit fear conditioning without effect on fear expression Walker and Davis, 2008
Chronic pain NR2B overexpression Forebrain Enhancing chronic pain Wei et al., 2002
  NR2B antagonist ACC Inhibiting chronic pain Wu et al., 2005