Table 2 Summary of the involvement of NMDA receptor NR2B subunit in behavioral memory and chronic pain
From: Plasticity of NMDA receptor NR2B subunit in memory and chronic pain
Brain function | Drug or manipulation | Brain regions | Effects | Reference |
|---|---|---|---|---|
Spatial memory (Morris water maze) | NR2B overexpression | Forebrain | Enhanced fear memory | Tang et al., 1999 |
NR2B antagonist | Systemic injection | No effect | Guscott et al., 2003 | |
Fear memory | NR2B overexpression | Forebrain | Enhanced fear memory | Tang et al., 1999 |
NR2B antagonist | Amygdala | Blocked acquisition | Rodrigues et al., 2001 | |
No effect on expression of fear | ||||
NR2B antagonist | Amygdala | Inhibit fear conditioning without effect on fear expression | Walker and Davis, 2008 | |
Chronic pain | NR2B overexpression | Forebrain | Enhancing chronic pain | Wei et al., 2002 |
NR2B antagonist | ACC | Inhibiting chronic pain | Wu et al., 2005 |