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Figure 1 | Molecular Brain

Figure 1

From: Transgenic up-regulation of alpha-CaMKII in forebrain leads to increased anxiety-like behaviors and aggression

Figure 1

Generation and expression analyses of alpha-CaMKII overexpressing mice. (A) Schematic representation of the alpha-CaMKII transgenic construct. (B) In situ hybridization analyses of transgene mRNA expression in the alpha-CaMKII overexpressing and WT mice. (C) Western blot analyses of the levels of alpha-CaMKII and phosphorylated alpha-CaMKII at T286 in the hippocampus, cortex, and cerebellum of alpha-CaMKII overexpressing and WT mice. Levels of alpha-CaMKII and phosphorylated alpha-CaMKII were normalized according to the levels of alpha-tubulin (hippocampus, WT, n = 7; alpha-CaMKII, n = 7; cortex, WT, n = 7; alpha-CaMKII, n = 7; cerebellum, WT, n = 5; alpha-CaMKII, n = 5). The asterisk indicates statistical significance at P < 0.05.

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