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Figure 2 | Molecular Brain

Figure 2

From: Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice

Figure 2

Effect of tdo deletion on systemic Trp metabolites. (A-H) Plasma amino acid composition and Trp metabolites in 18- to 20-week-old Tdo+/+ (+/+) and Tdo-/- (-/-) mice. Plasma Trp concentration (A), other essential amino acid (EAA-Trp) concentrations (B), and the ratio of Trp to large neutral amino acids (LNAA, H) were determined using an amino acid analyzer (means ± S.E.). **, p < 0.0001. Plasma levels of 5-HIAA (C), IAA (D), ILA (E), kynurenine (Kyn: F), kynurenic acid (KYNA: G) were determined using HPLC-FD and HPLC-UV systems. Values represent means ± S.E. *, p < 0.05.

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Molecular Brain

ISSN: 1756-6606