Figure 4

Anxiety-related behavior tests of 13- to 15-week-old Tdo^+/+ (+/+) and Tdo^-/- (-/-) mice. (A-C) Elevated plus maze tests. Duration in the open arms (A) and center zone (B), and total distance traveled (C) were scored for 5 min. Data represent the mean ± S.E. (D -F) Open field tests. The ratio between locomotion in the center and total locomotion (D), duration in the center zone (E), and total distance traveled (F) were scored for 30 min. Data represent the mean ± S.E. *, p < 0.05. **, p < 0.01. N.S., not significant.