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Table 1 Quantitative analysis of proliferating neural progenitors in SGZ 24 h after BrdU injection.

From: Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice

 

Nestin +

GFAP +

PSA-NCAM +

DCX +

Tdo +/+

2.78 ± 0.23

5.31 ± 0.49

4.20 ± 0.45

0.80 ± 0.08

Tdo -/-

2.38 ± 0.13

6.90 ± 0.26*

6.07 ± 0.48*

1.49 ± 0.13*

 

Nestin+/BrdU+

GFAP+/BrdU+

PSA+/BrdU+

DCX+/BrdU+

Tdo +/+

0.58 ± 0.12

0.34 ± 0.06

0.42 ± 0.08

0.77 ± 0.12

Tdo -/-

1.15 ± 0.13*

0.47 ± 0.05*

0.93 ± 0.09*

1.27 ± 0.11*

  1. Cells positive for neural progenitor markers, alone and in combination with BrdU, are indicated as a percentage of total cells. Cells were counted in >3 matched sections from the DG of each mouse (n = 3 for each genotype). These data represent means ± S.E. *, p < 0.05 versus Tdo+/+ mice (ANOVA, Scheffe's post-hoc test).
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Molecular Brain

ISSN: 1756-6606