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Figure 6 | Molecular Brain

Figure 6

From: Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice

Figure 6

Neuron loss occurred in the midbrain and the spinal cord of symptomatic A53T mice. (A) Representative images show TH and NeuN double staining in the SNpc area of symptomatic A53T mice and age-matched nTg littermates. Scale bars: 100 μm. (B) Representative images show NeuN staining in the ventral horn of lumbar spinal cord of symptomatic A53T mice and age-matched nTg littermates. Scale bar: 100 μm. (C) Bar graph depicts the numbers of TH-positive dopaminergic neurons in the SNpc and ventral tegmental area (VTA) of symptomatic A53T mice and nTg littermates (n = 3) estimated by unbiased stereological methods. *p < 0.05, **p < 0.01. (D) Bar graph reveals the numbers of motor neurons remained in the cervical and lumbar spinal cord of the symptomatic A53T mice and age-matched nTg littermates (n = 3). *p < 0.05.

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