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Figure 1 | Molecular Brain

Figure 1

From: CaMKIV over-expression boosts cortical 4-7 Hz oscillations during learning and 1-4 Hz delta oscillations during sleep

Figure 1

Experimental design. To examine behavioral states and freezing behavior, both WT and CaMKIV over-expressed mice were chronically instrumented with frontal-parietal EEG and EMG recording electrodes. Sleep and wakefulness recordings were obtained on the pre-conditioning day. Following the pre-conditioning day, between 7 and 8 AM, mice were trace fear conditioned. Mice were then returned to their home cage where their post-conditioning sleep was recorded. Trace fear conditioning was conducted for 45 minutes in a shock chamber. This paradigm involved repeated trials of a presentation of a tone, followed by an interval (trace interval) and subsequently by a foot shock. Trace fear testing was conducted the following day in a similar fashion, only in this case, the shock stimulus was omitted.

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