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Figure 2 | Molecular Brain

Figure 2

From: CaMKIV over-expression boosts cortical 4-7 Hz oscillations during learning and 1-4 Hz delta oscillations during sleep

Figure 2

CaMKIV over-expression enhances delta sleep in the recording environment. (A) Example raw traces of sleep measurements in WT and CaMKIV over-expressed mice for wakefulness, NREM and REM sleep. To the left is a depiction of the location of the recording electrodes. CaMKIV over-expressedmice demonstrate relatively normal EEG during wakefulness and REM sleep but had elevated slow oscillations during NREM sleep (arrow). The raw neck and the smoothed and rectified (Sm/Rt) neck signals show that EMG activity in CaMKIV over-expressed mice was relatively normal across sleep and wakefulness states. (B) CaMKIV over-expressed mice have normal wakefulness EEG power compared to WT mice. (C) CaMKIV over-expressed mice have enhanced delta EEG power in the 2-4 Hz range compared to WT mice. (D) CaMKIV over-expressed mice have normal REM sleep EEG power compared to WT mice. (E) CaMKIV over-expressed mice have normal neck EMG across all behavioral states compared to WT mice. W is wakefulness, * indicate significant differences compared to wild type (WT) mice with p < 0.05, Values are means + SEM.

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