Figure 3

CaMKIV over-expression enhances trace fear conditioning and subsequent memory. (A) Trace fear conditioning (30s trace interval) learning curve for both WT and CaMKIV over-expressed mice (* is p < 0.05 compared to baseline (BL)). CaMKIV over-expressed mice have enhanced fear behaviors during trace fear conditioning and testing above that of WT mice (# is p < 0.05). (B) Example of EMG-based freezing and scoring (red lines under the trace) from WT and CaMKIV over-expressed mice. Raw EMG data show periods of quiescence during the conditioning and memory trials of the mice. During conditioning and memory testing, CaMKIV over-expressed mice demonstrate more EMG-based freezing behavior than WT mice. S/ES represents shock and expected shock, for the conditioning and test trials respectively, AU is arbitrary units.