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Figure 4 | Molecular Brain

Figure 4

From: CaMKIV over-expression boosts cortical 4-7 Hz oscillations during learning and 1-4 Hz delta oscillations during sleep

Figure 4

CaMKIV over-expression and EEG responses to tone, trace interval and pain. CaMKIV over-expressed mice demonstrate alterations in EEG rhythms during different phases of trace fear conditioning. EEG data was averaged across every trial during trace fear conditioning (left side of graph) and again for every trial during memory testing (right side of graph) for WT and CaMKIV over-expressed mice. (A) None of the interventions had a significant effect on 1-2 Hz EEG power. (B) Trace fear training increased 2-4 Hz power in both WT and CaMKIV over-expressed mice above baseline (* is p < 0.05) for the trace interval. (C) Trace fear conditioning significantly enhanced 4-7.5 Hz EEG power in CaMKIV over-expressed mice for both the tone and the trace interval conditions compared to baseline. WT mice only demonstrated an enhancement in 4-7.5 Hz EEG power for the tone interval (* is p < 0.05). In addition, there was a significant enhancement in 4-7.5 Hz EEG power of CaMKIV over-expressed mice above that of WT mice for the trace interval during conditioning and the expected shock (E-Shock) and tone interval during memory testing (# is p < 0.05 compared to WT). (D) The baseline 7.5-13 Hz EEG power was increased in CaMKIV over-expressed mice with initial placement into the fear conditioning chamber (# is p < 0.05 compared to WT) and reduced during the tone, trace and E-shock intervals (* is p < 0.05 compared to baseline). (E) 13-20 Hz EEG power was reduced during the tone presentation on the test day relative to baseline in CaMKIV over-expressed mice. (F) None of the interventions had a significant effect on 20-30 Hz EEG power. BL is baseline, and values are means + SEM.

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