Figure 6

CaMKIV over-expression enhances slow delta oscillation power during NREM sleep before and after trace fear training. (A) Example of EEG sleep recording in the first hour, after the lights had been turned on, in the recording chamber for both CaMKIV over-expressed mice and WT mice. However, if the mouse had been trace fear conditioned, slow delta oscillation (1-4 Hz) enhancements were detected in the recording for CaMKIV over-expressedmice but not WT mice. (B) Group data showing that CaMKIV over-expressed mice have elevated slow delta oscillation power above that of WT mice during NREM sleep in the recording chamber across an 8 hour span. A subset of the CaMKIV over-expressed and WT mice were then recorded after trace fear training during the same time points of the next day. CaMKIV over-expressed mice were found to have elevated slow delta oscillations above that of the first hour of their pre-conditioning. However, WT mice did not show a similar enhancement. * is p < 0.05 compared to WT for the corresponding hour, # is p < 0.05 between pre and post-conditioning for the corresponding hour. (C) CaMKIV over-expressed and WT mice had similar 4-7.5 Hz power during REM sleep prior to and following trace fear conditioning. Four-7.5 HZ power was averaged across 4 hour time periods.