Skip to main content
Figure 9 | Molecular Brain

Figure 9

From: CaMKIV over-expression boosts cortical 4-7 Hz oscillations during learning and 1-4 Hz delta oscillations during sleep

Figure 9

Trace fear conditioning increases slow delta oscillations in the ACC in layer I-III. (A) Group data showing that the motor cortex (MTC) and the ACC (layer I-III electrode) field-potential (FP) slow wave oscillation power parallel one another on the pre-conditioning day (when their data is normalized to their average slow delta oscillation power across 8 hours). However, after the animals were trace fear conditioned, the slow delta oscillation power significantly increased in the ACC over that of the motor cortex (* is p < 0.05 compared to motor cortex post-conditioning). (B) Example of the slow delta oscillation during NREM sleep, recorded in the motor cortex (MTC) and the ACC before and after trace fear conditioning. When the mouse goes to sleep there is an increase in slow delta oscillation power in the EEG of the ACC with only a modest increase in the motor cortex. (C) Electrodes in the ACC that did not straddle layers I-III did not show and increase in slow delta oscillation power after trace fear conditioning. Indeed the motor cortex (MTC) served as a poor control for the ACC in these cases. This can be seen during the pre-conditioning session, in which the normalized slow wave oscillation power of the ACC and MTC activity did not overlap.

Back to article page