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Figure 2 | Molecular Brain

Figure 2

From: A study of long-term potentiation in transgenic mice over-expressing mutant forms of both amyloid precursor protein and presenilin-1

Figure 2

Age-dependent reduction in synaptic transmission in CA1 region of Wt and DbTg mice. (A) Individual examples of fEPSPs recorded with a stimulus intensity of 10, 20 and 30 V from slices prepared from 14 month old Wt and DbTg mice. Scale bar 0.5 mV, 10 ms. Stimuli were delivered at the times indicated by the arrows and stimulus artefacts have been removed for clarity. (B - D) Pooled data showing relationship between fEPSP slope and stimulus intensity at 2, 6, 9 and 14 months. In this and following figures symbols are [black circle] for Wt and [white circle] for DbTg results.

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