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Figure 5 | Molecular Brain

Figure 5

From: A study of long-term potentiation in transgenic mice over-expressing mutant forms of both amyloid precursor protein and presenilin-1

Figure 5

LTP induced by a theta burst stimulus is normal in DbTg mice. (A) Example experiment taken from 14 month old Wt slice. LTP was induced at the time indicated by the arrowhead. Example traces are taken from the time points immediately prior to and 60 min after the induction of LTP. Scale bar 0.5 mV, 20 ms. (B) Example experiment taken from 14 month old DbTg slice. (C) Pooled data for 2 month-old animals ([black circle] Wt, [white circle] DbTg). In this and subsequent figures showing pooled data, data points are shown at two minute intervals. (D) Summary of LTP as a percentage of baseline at 60 min post-tetanus for the different age groups. (E) Pooled data from a subset of slices from 14 month old animals where LTP was followed for 3.5 h after the theta burst. Scale bar 0.5 mV, 10 ms.

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Molecular Brain

ISSN: 1756-6606