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Figure 1 | Molecular Brain

Figure 1

From: Schizophrenia, amphetamine-induced sensitized state and acute amphetamine exposure all show a common alteration: increased dopamine D2 receptor dimerization

Figure 1

D2R expression in postmortem striatal tissue of schizophrenia patients. A. Representative Western blot analysis of the expression levels of D2R dimmers and monomers in human postmortem striatal sections of control, bipolar, depression and schizophrenia groups. α-tubulin was used as a loading control. B-C Bar graphs summarizing the Western blot data of D2R dimers (B) and monomers (C). *, ***Significantly different from control group (p < 0.05, p < 0.001; n = 15). Data were analyzed by One-way ANOVA, followed by SNK post-hoc test. D-E, Chronic haloperidol treatment caused no significant changes in the expression of D2R dimers and monomers in rat striatal tissue compare to control group (n = 12). Data were analyzed by t-test. F-G, Western blot analysis of the expression levels of D2R dimers (F) and monomers (G) in rat striatal slices treated with AMPH (30 min, 10 μM), in the presence or absence of haloperidol (30 min, 10 μM). *, **Significantly different from control group (p < 0.05, p < 0.01; n = 3). Data were analyzed by One-way ANOVA, followed by SNK post-hoc test.

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Molecular Brain

ISSN: 1756-6606