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Figure 8 | Molecular Brain

Figure 8

From: Expression of tryptophan 2,3-dioxygenase in mature granule cells of the adult mouse dentate gyrus

Figure 8

Immunoreactivity of TDO in the granule cells of CaMKIIα+/- mice. A: TDO was strongly expressed in the granule cells of wild-type mice, whereas TDO immunoreactivity was greatly reduced in CaMKIIα+/- mice, whose dentate gyrus (DG) granule cells display the physiologic and anatomic properties of immature cells. Note that interneurons in the hilus of both wild-type and CaMKIIα+/- mice expressed TDO, suggesting that the large decrease in TDO expression is specific to the DG granule cells. Higher magnification of the boxed-in area in each low-power image is displayed at the right of each lower-power image. B: Analysis of tdo expression with Real-time PCR. Total RNA was isolated from the DG of wild-type and CaMKIIα+/- mice. The expression of tdo mRNA in CaMKIIα+/- mice was significantly reduced to 0.39% of wild-type mice.

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