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Figure 3 | Molecular Brain

Figure 3

From: Calcium/calmodulin-dependent kinase IV contributes to translation-dependent early synaptic potentiation in the anterior cingulate cortex of adult mice

Figure 3

A transcription inhibitor has no effect on basal synaptic transmission. A: No effect of actinomycin-D (40 μM) on AMPA receptor-mediated EPSCs in ACC neurons of wild-type mice (n = 8/4 mice). B: No effect of actinomycin-D on NMDA receptor-mediated EPSCs in ACC neurons of wild-type mice (n = 6/3 mice). C: No effect of actinomycin-D on AMPA receptor-mediated EPSCs in ACC neurons of CaMKIV TG mice (n = 7/4 mice). D: No effect of actinomycin-D on NMDA receptor-mediated EPSCs in ACC neurons of CaMKIV TG mice (n = 6/3 mice). A-D: The dashed line indicating the mean basal synaptic responses. The insets showing averages of five EPSCs at baseline responses (a) and 25-30 min (b) after application of actinomycin-D (black bar).

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Molecular Brain

ISSN: 1756-6606