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Figure 4 | Molecular Brain

Figure 4

From: DREAM (Downstream Regulatory Element Antagonist Modulator) contributes to synaptic depression and contextual fear memory

Figure 4

Reduced NMDA receptor-mediated synaptic transmission in TgDREAM mice. (A) Input-output relationship for NMDA receptor-mediated EPSCs evoked by various stimulation intensities in wild-type mice (filled circles, n = 8) and TgDREAM mice (open circles, n = 7). The amplitude of NMDA receptor current in TgDREAM mice was significantly reduced compared with that in wild-type mice. * P < 0.05. The right panel shows representative traces for NMDA receptor-mediated EPSCs in wild-type and TgDREAM mice. (B) The percentage of NR2A or NR2B component of NMDA receptor-mediated EPSCs is similar in the TgDREAM (n = 7) and wild-type mice (n = 7). The right panel shows sample traces of NMDAR-mediated EPSCs in control, 0.4 μM NVP-AAM077 (NVP) and 0.4 μM NVP-AAM077 + 3 μM ifenprodil (NVP + Ifen) in wild-type and TgDREAM mice.

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Molecular Brain

ISSN: 1756-6606