Figure 7

Normal AMPA receptor function and expression inTgDREAM mice. (A) Input-output relationship for AMPA receptor-mediated EPSCs in wild-type (filled circles, n = 7) and TgDREAM mice (open circles, n = 7). There is no significant difference between the two groups. The sample traces are shown in the right panel. (B) Representative western blot (left) and quantified data (right) for expression levels of GluR1 and GluR2&3 subunits in hippocampus from wild-type and TgDREAM mice. Data were normalized to expression level of wild-type mice (n = 4 for each group). (C) Representative western blot (left) and quantified data (right) for phosphorylation of AMPA GluR1 receptor at ser831 and 845 sites in hippocampus from wild-type and TgDREAM mice. Data were normalized to expression level of wild-type mice (n = 4 for each group).