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Figure 1 | Molecular Brain

Figure 1

From: Altered synaptic plasticity in the mossy fibre pathway of transgenic mice expressing mutant amyloid precursor protein

Figure 1

Altered short term plasticity in the mossy fibre pathway of Tg2576 mice. A) Pooled input-output curves from 8 WT and 8 Tg2576 recordings of mossy-fibre transmission. The graph plots applied stimulus strength versus EPSP amplitude. The inset traces illustrate overlaid responses to 50, 150 and 300 μA stimulation in the indicated genotype. Scale bar 10 ms, 0.5 mV. B) Pooled paired pulse facilitation data for inter-stimulus intervals from 10 to 1000 ms. The graph plots, for each inter-stimulus interval, the amplitude of the second evoked EPSP as a fraction of the first. The example recordings illustrate responses to paired stimuli with interstimulus intervals of 10-100 ms with a quarter log spacing. Data are from typical WT and Tg2567 recordings as indicated. Scale bar: 30 ms, 1 mV. C) The symbols plot, for WT and Tg2576 mice, the frequency facilitation profiles elicited by 20 pulse 1 Hz stimulus trains. The amplitude of the nth EPSP of the train is plotted relative to the response to the 1st stimulus. The grey line without symbols plots the ratio of the facilitation in Tg2576 slices to that in WT slices, and illustrates how the divergence grows rapidly over the first few stimuli. The traces to the left are overlays of the 1st, 3rd and 20th fEPSPs in example WT and Tg2576 recordings. Scale bar: 10 ms, 1 mV. D) A graph plotting the mean facilitation time constant for WT and Tg2576 recordings. These were derived by fitting single exponential functions to the frequency facilitation exhibited by each recording. The data reveal there was no difference in facilitation rate between WT and Tg2576 recordings. The units on the ordinate are stated in seconds but also could be quoted as number of stimuli. The data in B-D were obtained from 8 slices in each group, these were obtained from 5 WT and 7 Tg2576 mice, respectively.

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