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Figure 1 | Molecular Brain

Figure 1

From: Lack of interleukin-1 type 1 receptor enhances the accumulation of mutant huntingtin in the striatum and exacerbates the neurological phenotypes of Huntington's disease mice

Figure 1

Lack of IL-1RI leads to rotarod deficits in N171-82Q mice. (A) Genomic DNA PCR analysis of mice of different genotypes. N171-82Q mice with (HD-IL-1R+/-) or without (HD-IL1R-/-) one copy of the IL-1RI gene were used for further comparison. Wild type (350 bp) and mutant (172 bp) IL1R products are indicated. (B) Male and female rotarod performances of (HD-IL1R+/-), (HD-IL1R-/-), 1R+/-, and 1R-/- mice at the age of 3 months were examined and compared. n = 10 each group. (C) The rotarod performance of both male and female mice of different genotypes as indicated in (B). n = 10 each group. ** p < 0.01.

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