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Figure 2 | Molecular Brain

Figure 2

From: Lack of interleukin-1 type 1 receptor enhances the accumulation of mutant huntingtin in the striatum and exacerbates the neurological phenotypes of Huntington's disease mice

Figure 2

Increased accumulation of mutant htt in the HD mouse brain when IL-1RI is absent. (A) EM48 immunostaining (20×) showing the increased staining of mutant htt in the brain regions [cortex, striatum, lateral globus pallidus (LGP), hippocampus] of HD-IL1R-/- mice compared with HD-IL1R+/- mice. This increase is more prominent in the striatum of HD-IL1R-/- mice. (B) Fluorescent staining showing that mutant htt (green) is more abundant in the nuclei (blue), with small aggregates that are outside the nucleus and that were characterized previously as neuropil htt aggregates.

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Molecular Brain

ISSN: 1756-6606