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Figure 2 | Molecular Brain

Figure 2

From: Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease

Figure 2

Effects of behavioral stress on Aβ load in the hippocampus of 5XFAD mice. Mice were exposed to restraint stress for 6 h per day during 5 consecutive days and were sacrificed for analysis 24 h after the last stress treatment. Brain sections from male (A, B) and female (D, E) 5XFAD mice were immunostained with the 6E10 anti-Aβ antibody. Shown are representative photomicrographs of the hippocampus of 5XFAD mice with (B, E) or without (A, D) stress treatments. Scale bar = 500 μm. Percentage area occupied by amyloid deposits in the hippocampus of male (C) and female (F) 5XFAD mice was measured for quantification (n = 6-7 mice per group). Note that hippocampal plaque burden is significantly increased in stressed female but not male 5XFAD mice as compared with non-stressed controls (* p < 0.05). All data are presented as mean ± SEM.

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