Figure 7

p-GBA and AN have no or weak effects on TRPM7 current in hippocampal neurons. A, chemical formulas of NM, p-GBA/AN, DAPI, HSB, gabexate, netropsin, synthalin. B, left, bar-graph of normalized current showing co-applied p-GBA (1 mM) did not block TRPM7 current. I _p-GBA /I _control was 94 ± 3%, p = 0.23, n = 4. Right, bar-graph; pre-exposed p-GBA (1 mM) did not potentiate TRPM7 current. I _p-GBA /I _control was 96 ± 1%, p = 0.86, n = 3. C, left, co-applied AN (1 mM) slightly blocked TRPM7 current. I _AN /I _control was 69 ± 29%, p = 0.03, n = 6. Right, pre-applied AN (200 μM) did not potentiate TRPM7 current. I _AN /I _control was 85 ± 5%, p = 0.6, n = 5.