Figure 3
From: Pyk2 uncouples metabotropic glutamate receptor G protein signaling but facilitates ERK1/2 activation
Pyk2 expression has no effect on agonist-independent receptor internalization. HEK293 cells transfected with 5 μg of pcDNA3.1 cDNA encoding FLAG-mGluR1a with and without either 5 μg of empty pcDNA3.1 plasmid cDNA or 5 μg of pcDNA3.1 plasmid cDNA encoding HA-Pyk2 were treated with and without 100 μM quisqualate for different time points. The data represent the mean ± S.E.M. of 9 independent experiments.