Figure 2
From: Presenilins and the γ-secretase: still a complex problem
Hypothetical model showing how γ-secretase/PS may cleave C99 to yield Aβ. In this model, PS contains 2 catalytic aspartyl residues (D) that form part of the active site. The two residues are in an aqueous environment formed by a pocket on one side of the membrane. After cleavage of APP by BACE1, the product, C99, is destabilised and slips into the active site where it is cleaved to form Aβ and the APP intracellular domain (AICD).