Figure 6

Changes in sleep behavior due to disruption of activity-dependent BDNF expression. (A). Total time over a 24 h session spent sleeping by WT and BDNF KIV mice (n = 8 each genotype). (B). Hour-by-hour plot of sleep behavior over the 24 h period with lights off phase (1-12 h) indicated by shading. (C). Hour-by-hour plot of sleep behavior under conditions of constant darkness. Dark shaded area represents period of time corresponding to animals' original lights off, active phase. Arrows point to conserved rest periods during the active phase in WT animals (n = 4 each genotype).