Figure 3

Effects of FLX14 on locomotor activity and anxiety-related behavior. (A) FLX14 reduced the total distance traveled in the open-field test (z = 2.094, p = 0.0363), but had no significant effect on time spent in the center of the field (z = 0.952, p = 0.3412, CNT: n = 13, FLX14: n = 12). Time in center is indicated as percent time spent in the center relative to the total time in the field. (B) FLX14 reduced the total distance traveled in the light/dark transition test (z = 2.203, p = 0.0276), but had no significant effects on the number of transition between two compartments (z = 0.952, p = 0.3408), time spent in the light box (z = 0.408, p = 0.6833), or latency to enter the light box (z = 1.822, p = 0.0685, CNT: n = 13, FLX14: n = 12). Time in light is indicated as percent time spent in the light compartment relative to the total test time. (C) In the elevated plus-maze test, FLX14 had no significant effects on the total distance traveled (z = 0.68, p = 0.4966), the total number of entries into arms (z = 0.897, p = 0.3693), time spent on open arms (z = 1.523, p = 0.1278), or entry into open arms (z = 1.768, p = 0.0772, CNT: n = 13, FLX14: n = 12). Time in open arms and open arm entry are indicated as percent time spent on open arms relative to the total test time and the percent number of entries into open arms relative to the total number of entries, respectively. Data are presented as mean ± s.e.m.