Figure 7

Effects of fluoxetine on anxiety- and depression-related behaviors in wild-type littermates of 5-HT ₄ -deficient mice. (A) FLX22 reduced time spent in the center of the open field (U = 3, p = 0.0003), but had no significant effect on the total distance traveled (U = 28, p = 0.3154) in 5-HT₄+/+ mice (CNT: n = 10, FLX22: n = 8). (B) FLX22 reduced the total distance traveled (U = 15, p = 0.0464), the number of transition (U = 2.5, p = 0.0003), and time spent in the light compartment (U = 0, p < 0.0001) and increased the latency to enter the light compartment (U = 6, p = 0.0025) in the light/dark transition test in 5-HT₄+/+ mice (CNT: n = 9, FLX22: n = 8). Four fluoxetine-treated mice did not enter the light compartment. (C) FLX22 had no significant effects on the total distance traveled (U = 36, p = 0.7618), the total number of entries into arms (U = 31, p = 0.4598), time spent on open arms (z = 0.8, p = 0.4082), or entry into open arms (U = 20, p = 0.0831) in elevated plus-maze test in 5-HT₄+/+ mice (CNT: n = 10, FLX22: n = 8). (D) FLX22 increased immobile time in forced swim test in 5-HT₄+/+ mice (CNT: n = 10, FLX22: n = 8, U = 11, p = 0.0085), but had no significant effect in the tail suspension test (U = 19, p = 0.0676). Percent values are calculated as in Figure 3 and 5.