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Figure 1 | Molecular Brain

Figure 1

From: si-RNA inhibition of brain insulin or insulin-like growth factor receptors causes developmental cerebellar abnormalities: relevance to fetal alcohol spectrum disorder

Figure 1

Effects of si-InR, si-IGF-1R, and si-IGF-2R ICV injections on motor performance. P2 Long Evans rat pups were administered intracerebroventricular (ICV) injections of si-RNA targeting the insulin receptor (InR), insulin-like growth factor type 1 receptor (IGF-1R), IGF-2R, or nonspecific sequences (Scr). On P20, rats were subjected to 10 incremental speed trials (from 2 to 10 rpm) of rotarod testing of motor function. Each trial was limited to 30 seconds duration. Data from (A) Trials 1-3 (2-4.5 rpm), (B) Trials 4-6 (5-7.5 rpm), and (C) Trials 7-10 (8-10 rpm) were culled and analyzed using the Mann-Whitney test. Panels display box plots with means (bar), 95% confidence limits (box) and range (whiskers). Significant P-values are indicated within the panels.

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Molecular Brain

ISSN: 1756-6606