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Figure 3 | Molecular Brain

Figure 3

From: si-RNA inhibition of brain insulin or insulin-like growth factor receptors causes developmental cerebellar abnormalities: relevance to fetal alcohol spectrum disorder

Figure 3

Inhibition of insulin and IGF signaling mechanisms in cerebella following ICV si-RNA delivery. Long Evans rat pups were administered ICV injections of si-Scr, si-InR, si-IGF-1R, or si-IGF-2R on P2. Cerebella harvested on P24 were used to measure (A) insulin, (B) IGF-1, (C) IGF-2, (D) insulin R, (E) IGF-1R, and (F) IGF-2R expression by qRT-PCR analysis with results normalized to 18S rRNA. Box plots depict means, 95% confidence intervals, and range for each group. Inter-group statistical comparisons were made using the Kruskal-Wallis one-way ANOVA and the Dunn's multiple comparisons post hoc test. Significant P-values are indicated within the panels.

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