Figure 3
From: Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness
Neuronal signaling of the 5-HT1A autoreceptor. The major signaling pathways of the 5-HT1A receptor in neurons are shown. The 5-HT1A receptor is shown figuratively as a heptahelical G-protein coupled receptor that couples via inhibitory G proteins (Gi/Go) to inhibit adenylyl cyclase (AC) and reduce cAMP levels; to open G-protein inward rectifying potassium channels (K+) to reduce membrane potential (Vm); and to inhibit voltage-gated calcium channels (Ca++) and reduce intracellular free calcium concentration ([Ca++]i).