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Figure 4 | Molecular Brain

Figure 4

From: Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness

Figure 4

Identified promoter elements of the human 5-HT1A receptor gene (HTR1A). The location of identified DNA elements on the 5-HT1A 5' regions flanking the start of translation (bold arrow) are shown figuratively. Identified activators (arrows) or repressors (bars) of transcription are also shown. Within the minimal promoter (box) there are GC-rich Sp1 and MAZ elements (+); NFkB response element (NRE); and glucocorticoid receptors (GR/MR) that inhibit transcription by blocking Sp1. Further upstream in a repressor/enhancer regions, a negative glucocorticoid response element (nGRE) also mediates direct GR/MR-induced repression. Hes and Deaf1 proteins repress the 5-HT1A promoter at the C(-1019) allele, while in serotonin neurons Pet-1 exerts strong enhancer activity. A strong repressor region that silences expression in 5-HT1A-negative non-neuronal cells, but also represses in 5-HT1A-positive neuronal cells is located upstream that includes elements for REST (RE-1), Freud-1 and Freud-2 (DRE).

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