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Figure 1 | Molecular Brain

Figure 1

From: Antiretroviral medications disrupt microglial phagocytosis of β-amyloid and increase its production by neurons: Implications for HIV-associated neurocognitive disorders

Figure 1

ART medications increase Aβ generation in cultured neuronal cells. Total Aβ 1-40,42 peptides were analyzed in conditioned media from SweAPP N2a cells by ELISA (n = 2 for each condition). Data are represented as a mean ± SEM percentage of Aβ 1-40,42 peptides secreted 18 hours after antiretroviral treatment relative to control (untreated). One-way ANOVA followed by post hoc comparison revealed significant increases in Aβ 1-40,42 production following 3TC/Indinavir, 3TC/Abacavir, and Indinavir/Abacavir treatements (concentration of 10 μM for each individual compound; p < 0.05).

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Molecular Brain

ISSN: 1756-6606