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Figure 2 | Molecular Brain

Figure 2

From: Antiretroviral medications disrupt microglial phagocytosis of β-amyloid and increase its production by neurons: Implications for HIV-associated neurocognitive disorders

Figure 2

ART medications inhibit microglial phagocytosis of Aβ 1-42 peptides. N9 microglia were treated with "aged" FITC-tagged Aβ 1-42 (300 nM) in complete medium for 120 min in the presence of 10 μM concentrations of antiretrovirals. Total FITC-Aβ1-42 peptides were analyzed by fluorescence from conditioned media (extracellular; top) and cell lysates (phagosomal/cell associated; bottom). Data are represented as the relative mean ± SEM fluorescence (n = 4 for each condition presented). When measuring extracellular FITC-tagged Aβ 1-42, one-way ANOVA followed by post hoc comparison showed significantly higher levels following all antiretroviral treatments, as compared to control (p < 0.05). When measuring cell associated FITC-tagged Aβ 1-42, one-way ANOVA followed by post hoc comparison showed significantly lower levels following Indinavir, Abacavir, AZT/3TC, AZT/Abacavir, 3TC/Indinavir, and Indinavir/Abacavir, as compared to control (p < 0.05).

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