Genomic region harboring copy number loss on 19p13.3 in patients with MSA. Data measured by CNV 57K beadchip analysis were analyzed by using the Hidden Malcov Model. The genomic structures of 100 normal control subjects (top) and 33 patients with MSA (bottom) are horizontally aligned from position 000,000 (left) to position 5,000,000 (right). Each blue square represents copy number loss at each CNV probe site whereas each red square represents copy number gain. The horizontal blue bars at the bottom show the distal 350-kb region and proximal 1-Mb region with frequent copy number loss. The asterisks to the bottom left indicate cases of SHC2 deletion. The bottom map shows the positions of putative genes in the region .