Figure 7

Modeling of the nitrated tyrosine residues of PKM2. A) Location of the nitrated tyrosines on one subunit of the PK tetramer. Nitrated tyrosine residues are represented as sticks colored by atom type (green, carbon; blue, nitrogen; red, oxygen). Detailed view of the environment of the nitrated tyrosines. B) Tyr 175 at the interface of the A-domain (green) and B-domain of neighbor subunit (magenta). C) Tyr 105 at the B/C interface. Possible and actual hydrogen bonds are represented as dashed blue lines. Steric contacts are indicated with dashed red lines. Modeling and figures were done with the program PyMOL (TM Schrodinger, LLC).