Figure 3

Effect of fetal alcohol exposure on associative olfactory task performance. (a) Adult control and FAE mice were trained to discriminate between two relatively distinct odors (100:0) or two relatively similar odors (80:20), with a 10 min (100:0: control n = 7, FAE n = 8; 80:20: control n = 9, FAE n = 9), 24 hour (100:0: control n = 8, FAE n = 8; 80:20: control n = 9, FAE n = 9), or 7 day (100:0: control n = 9, FAE n = 9; 80:20: control n = 10, FAE n = 9) delay between training and testing. (b) Both control and FAE mice spent more time digging at the + odor compared to the -odor during training. (c,d) Both control and FAE mice discriminated between + and -odors when the odors were relatively distinct (100:0 vs. 0:100), regardless of the delay between training and testing. (e,f) FAE mice failed to discriminate between + and -odors when the odors were relatively similar (80:20 vs. 20:80).