Figure 4
From: DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze
Enhanced synaptic plasticity in DIP knockout mice. (A) Long-term potentiation (LTP) induced by high-frequency stimulation (2 trains of 100 Hz with each train lasting 1 sec with an inter-train interval of 10 secs) was significantly enhanced (P < 0.05) in DIP knockout slices (190 ± 6.3%; n = 7) in comparison to wild-type slices (160 ± 11.6%; n = 7). (B) Comparison of the last 10 minutes of potentiation between DIP knockout mice and wild-type controls following the administration of HFS.